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dysregulation, polyendocrinopathy, enteropathy, X-linked\uff09\u75c7\u5019\u7fa4\u60a3\u8005\u306b\u767a\u75c7\u3059\u308b\u81f4\u6b7b\u7684\u306a\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u3068\u3057\u3066\u300cFoxp3\u300d\u3092\u767a\u898b\u30022003\u5e74\u3001\u5742\u53e3\u6c0f\u3089\u306fFoxp3\u304cTreg\u7d30\u80de\u306b\u9078\u629e\u7684\u306b\u767a\u73fe\u3057\u3001\u305d\u306e\u767a\u751f\u30fb\u5206\u5316\u3068\u514d\u75ab\u6291\u5236\u6a5f\u80fd\u3092\u3064\u304b\u3055\u3069\u308b\u300c\u30de\u30b9\u30bf\u30fc\u8ee2\u5199\u56e0\u5b50\u300d\u3068\u3057\u3066\u50cd\u304f\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u767a\u898b\u306b\u3088\u308a\u3001\u514d\u75ab\u5236\u5fa1\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u5b8c\u5168\u306b\u89e3\u660e\u3055\u308c\u307e\u3057\u305f\u3002\u7d0440\u5e74\u306b\u308f\u305f\u308b\u57f7\u5ff5\u306e\u7814\u7a76\u304c\u3001\u3064\u3044\u306b\u7d50\u5b9f\u3057\u305f\u77ac\u9593\u3067\u3057\u305f\u3002<\/p>\n<h2>\u5236\u5fa1\u6027T\u7d30\u80de\u3068\u306f\uff1f\u514d\u75ab\u306e\u300c\u30d6\u30ec\u30fc\u30ad\u5f79\u300d\u306e\u6b63\u4f53<\/h2>\n<p>\u5236\u5fa1\u6027T\u7d30\u80de\uff08Treg\uff09\u306f\u3001\u514d\u75ab\u5fdc\u7b54\u3092\u6291\u5236\u3057\u3001\u904e\u5270\u306a\u708e\u75c7\u3084\u81ea\u5df1\u514d\u75ab\u53cd\u5fdc\u3092\u9632\u3050\u91cd\u8981\u306a\u7d30\u80de\u3067\u3059\u3002\u5065\u5e38\u4eba\u306e\u672b\u68a2\u8840\u306b\u3042\u308bCD4+T\u7d30\u80de\u306e\u3046\u3061\u3001\u6982\u306d5%\u7a0b\u5ea6\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u767a\u75c7\u3092\u9632\u3050\u305f\u3081\u306b\u81ea\u5df1\u306b\u5bfe\u3059\u308b\u514d\u75ab\u5fdc\u7b54\u3092\u6291\u5236\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u79c1\u305f\u3061\u306e\u4f53\u306b\u306f\u3001\u7d30\u83cc\u3084\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u306e\u5916\u6575\u3092\u653b\u6483\u3059\u308b\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304c\u66b4\u8d70\u3059\u308b\u3068\u3001\u81ea\u5206\u81ea\u8eab\u306e\u7d30\u80de\u3084\u7d44\u7e54\u3092\u653b\u6483\u3057\u3066\u3057\u307e\u3046\u300c\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u300d\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u5236\u5fa1\u6027T\u7d30\u80de\u306f\u3001\u307e\u3055\u306b\u3053\u306e\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u300c\u30d6\u30ec\u30fc\u30ad\u5f79\u300d\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001\u514d\u75ab\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u4fdd\u3064\u5b88\u8b77\u795e\u306e\u3088\u3046\u306a\u5b58\u5728\u306a\u306e\u3067\u3059\u3002<\/p>\n<p>\u5742\u53e3\u6c0f\u306e\u767a\u898b\u306b\u3088\u308a\u3001\u300c\u514d\u75ab\u306b\u306f\u653b\u6483\u3059\u308b\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u3001\u653b\u6483\u3092\u6b62\u3081\u308b\u7d30\u80de\u3082\u5b58\u5728\u3059\u308b\u300d\u3068\u3044\u3046\u514d\u75ab\u5b66\u306e\u65b0\u3057\u3044\u30d1\u30e9\u30c0\u30a4\u30e0\u304c\u78ba\u7acb\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u514d\u75ab\u5b66\u306e\u6559\u79d1\u66f8\u3092\u66f8\u304d\u63db\u3048\u308b\u9769\u547d\u7684\u306a\u767a\u898b\u3067\u3057\u305f\u3002<\/p>\n<h3>\u5236\u5fa1\u6027T\u7d30\u80de\u306e\u8a73\u7d30\u30e1\u30ab\u30cb\u30ba\u30e0<\/h3>\n<p>\u5236\u5fa1\u6027T\u7d30\u80de\u306f\u3001\u8907\u6570\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u3063\u3066\u514d\u75ab\u5fdc\u7b54\u3092\u5236\u5fa1\u3057\u3066\u3044\u307e\u3059\u3002\u4e3b\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u306f\u4ee5\u4e0b\u306e\u3082\u306e\u304c\u3042\u308a\u307e\u3059\uff1a<\/p>\n<ul>\n<li><strong>\u6291\u5236\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u5206\u6ccc\uff1a<\/strong>IL-10\u3001TGF-\u03b2\u3001IL-35\u306a\u3069\u306e\u6291\u5236\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u5206\u6ccc\u3057\u3001\u4ed6\u306e\u514d\u75ab\u7d30\u80de\u306e\u6d3b\u52d5\u3092\u6291\u5236<\/li>\n<li><strong>CTLA-4\u3092\u4ecb\u3059\u308b\u5236\u5fa1\uff1a<\/strong>\u6297\u539f\u63d0\u793a\u7d30\u80de\uff08APC\uff09\u306e\u6d3b\u52d5\u3092\u5236\u5fa1\u3057\u3001T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236<\/li>\n<li><strong>IL-2\u306e\u596a\u53d6\uff1a<\/strong>\u4ed6\u306eT\u7d30\u80de\u306e\u5897\u6b96\u306b\u5fc5\u8981\u306aIL-2\u3092\u6d88\u8cbb\u3059\u308b\u3053\u3068\u3067\u3001\u904e\u5270\u306a\u514d\u75ab\u5fdc\u7b54\u3092\u6291\u5236<\/li>\n<li><strong>\u76f4\u63a5\u7684\u306a\u7d30\u80de\u9593\u76f8\u4e92\u4f5c\u7528\uff1a<\/strong>\u30a8\u30d5\u30a7\u30af\u30bf\u30fcT\u7d30\u80de\u3068\u76f4\u63a5\u63a5\u89e6\u3057\u3001\u305d\u306e\u6d3b\u52d5\u3092\u6291\u5236<\/li>\n<\/ul>\n<p>\u3053\u308c\u3089\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u5354\u8abf\u7684\u306b\u50cd\u304f\u3053\u3068\u3067\u3001\u5236\u5fa1\u6027T\u7d30\u80de\u306f\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u7cbe\u5bc6\u306a\u30d0\u30e9\u30f3\u30b9\u3092\u7dad\u6301\u3057\u3066\u3044\u3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